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Furthermore, when using perchloric acid in a laboratory setting, one must be cautious of its potential to form explosive mixtures with organic compounds. The combination of strong oxidizers with organic materials under specific conditions can lead to hazardous situations. Consequently, thorough training and safety measures should be in place when handling perchloric acid, especially in glacial acetic acid mediums.

Proper training for all personnel who handle glacial acetic acid is essential. Workers should be familiar with the properties of the acid, the significance of safety data sheets (SDS), and the procedures for emergency response in case of spills or exposures. Additionally, having a contingency plan that includes evacuation procedures and first aid measures can make a substantial difference in minimizing the impact of an incident.

In addition to its liquid form, glacial acetic acid can form acidic and basic medium depending on the pH level. It exhibits corrosive properties, meaning it can cause burns upon contact with skin or eyes. Hence, it is crucial to handle it with appropriate safety measures and equipment.